Coronary Flow Reserve, Inflammation, and Myocardial Strain: The CIRT-CFR Trial.

Abstract

Inflammation is a key determinant of cardiovascular outcomes, but its role in heart failure is uncertain. In patients with cardiometabolic disease enrolled in the prospective, multicenter ancillary study of CIRT (Cardiovascular Inflammation Reduction Trial), CIRT-CFR (Coronary Flow Reserve to Assess Cardiovascular Inflammation), impaired coronary flow reserve was independently associated with increased inflammation and myocardial strain despite well-controlled lipid, glycemic, and hemodynamic profiles. Inflammation modified the relationship between CFR and myocardial strain, disrupting the association between cardiac blood flow and function. Future studies are needed to investigate whether an early inflammation-mediated reduction in CFR capturing microvascular ischemia may lead to heart failure in patients with cardiometabolic disease. (Cardiovascular Inflammation Reduction Trial [CIRT]; NCT01594333; Coronary Flow Reserve to Assess Cardiovascular Inflammation [CIRT-CFR]; NCT02786134).

• Authors: Viviany R Taqueti, Amil M Shah, Brendan M Everett, Aruna D Pradhan, Gregory Piazza, Courtney Bibbo, Jon Hainer, Victoria Morgan, Ana Carolina do A H de Souza, Hicham Skali, Ron Blankstein, Sharmila Dorbala, Samuel Z Goldhaber, Michel R Le May, Benjamin J W Chow, Robert A deKemp, Fadi G Hage, Rob S Beanlands, Peter Libby, Robert J Glynn, Scott D Solomon, Paul M Ridker, Marcelo F Di Carli
• Journal: JACC. Basic to translational science (JACC Basic Transl Sci) Vol. 8 Issue 2 Pg. 141-151 (Feb 2023) ISSN: 2452-302X [Electronic] United States
• PMID: 36908662 (Publication Type: Journal Article)
• Copyright: © 2022 Published by Elsevier on behalf of the American College of Cardiology Foundation.