Autoantibodies against type I interferons in COVID-19 infection: A systematic review and meta-analysis.
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| Abstract | OBJECTIVES: In this study, we aimed to study the rate of autoantibodies against type I interferons (IFNs) in patients with COVID-19 and analyze its dependence on severity of infection and some other variables. METHODS: A systemic review with the search terms: "COVID-19" or "SARS-CoV-2" and "autoantibodies" or "autoantibody" and "IFN" or "interferon" for the period 20 December 2019 to 15 August 2022 was carried out using PubMed, Embase, Cochrane, and Web of Science. R 4.2.1 software was used for meta-analysis of the published results. Pooled risk ratios and 95% confidence intervals (CIs) were calculated. RESULTS: We identified eight studies involving 7729 patients, of whom 5097 (66%) had severe COVID-19 and 2632 (34%) had mild or moderate symptoms. The positive rate of anti-type-I-IFN-autoantibodies in the total dataset was 5% (95% CI, 3-8%), but reached 10% (95% CI, 7-14%) in those with severe infection. The most common subtypes were anti-IFN-α (89%) and anti-IFN-ω (77%). The overall prevalence in male patients was 5% (95% CI, 4-6%), and in female patients 2% (95% CI, 1-3%). CONCLUSION: Severe COVID-19 is associated with high rates of autoantibodies against type-I-IFN and more so in male than female patients.
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| Authors | Xi Wang, Qi Tang, Hongmei Li, Honglin Jiang, Jing Xu, Robert Bergquist, Zhiqiang Qin |
| Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 130 Pg. 147-152 (May 2023) ISSN: 1878-3511 [Electronic] Canada |
| PMID | 36907547 (Publication Type: Meta-Analysis, Systematic Review, Journal Article) |
| Copyright | Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
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