Abstract |
Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the response to immune checkpoint inhibitors (ICIs). In this review, it was attempted to summarize the current knowledge about the influences of both sex and gut microbiome on the antitumor efficacy of ICIs and describe the interaction between sex hormones and gut microbiome. Accordingly, this review discussed the potential of enhancing the antitumor efficacy of ICIs through regulating the levels of sex hormones through manipulation of gut microbiome. Collectively, this review provided reliable evidence concerning the role of the sex hormone-gut microbiome axis in tumor immunotherapy.
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Authors | Luoyang Wang, Lei Tang, Dongchang Zhai, Meiying Song, Wei Li, Shuo Xu, Suli Jiang, Haining Meng, Jie Liang, Yingying Wang, Bei Zhang |
Journal | Gut microbes
(Gut Microbes)
2023 Jan-Dec
Vol. 15
Issue 1
Pg. 2185035
ISSN: 1949-0984 [Electronic] United States |
PMID | 36880651
(Publication Type: Review, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gonadal Steroid Hormones
- Immune Checkpoint Inhibitors
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Topics |
- Humans
- Gastrointestinal Microbiome
- Immunotherapy
- Gonadal Steroid Hormones
- Immune Checkpoint Inhibitors
(therapeutic use)
- Neoplasms
(therapy)
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