Abstract | Purpose: Patients and Methods: The study retrospectively analysed 8 patients with persistent hematuria and proteinuria at different onset ages who were diagnosed with XLAS and been treated with HCQ. The urinary erythrocyte count, urinary albuminn were measured. Descriptive statistics were used to estimate the patients' responses to HCQ treatment after one month, three months, and six months. Results: After the first month, the three months, and the six months of HCQ treatment, the urinary erythrocyte counts of four, seven, and eight children were significantly reduced; the decreasing proteinuria was found in two, four, and five children. Only one child with increasing proteinuria was found after 1-month HCQ treatment. This proteinuria was maintained after 3-month HCQ treatment but decreased to minor after 6-month HCQ treatment. Conclusion: We present the first potential efficacy of HCQ treatment in XLAS with hematuria and persistent proteinuria. It suggested that HCQ could be an effective treatment to ameliorate hematuria and proteinuria.
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Authors | Lei Sun, Xin-Yu Kuang, Jing Zhang, Wen-Yan Huang |
Journal | Pharmacogenomics and personalized medicine
(Pharmgenomics Pers Med)
Vol. 16
Pg. 145-151
( 2023)
ISSN: 1178-7066 [Print] New Zealand |
PMID | 36874354
(Publication Type: Journal Article)
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Copyright | © 2023 Sun et al. |