Dengue is a common arthropod-borne life-threatening febrile illness. This disease affects liver functions with an imbalance of liver
enzymes followed by other clinical manifestations. The
dengue serotypes can cause
asymptomatic infection to more severe versions of hemorrhagic
fever and
dengue shock syndrome in West Bengal and around the globe. The main aim of this study is to establish how different liver
enzymes act in identifying markers for
dengue prognosis for the early detection of
severe dengue fever (DF). The diagnosis of
dengue patients was confirmed by
enzyme-linked
immunosorbent assay, and associated clinical parameters [
aspartate transaminase (AST),
alanine aminotransferase (ALT),
alkaline phosphatase, total
bilirubin, total
albumin, total
protein, packed cell volume, and platelet count] were analyzed. Furthermore, the viral load estimation was also carried out by RT PCR analysis. The majority of these patients had elevated AST and ALT levels; ALT levels were higher than AST levels, which were partially observed in all non-structural
protein 1
antigen- and
dengue immunoglobulin M antibody-reactive patients. Almost 25% of patients had very low platelet count or
thrombocytopenia. Furthermore, the viral load shows a significant association with all the clinical parameters with a p-value of <0.0001. All these liver
enzymes are significantly correlated with an increased level of T.BIL, ALT, and AST. This study depicts that the intensity of hepatic involvement may play a critical role in the morbidity and mortality of DF patients. As a result, all of these liver parameters can be useful early markers for determining the severity of the disease, allowing for early detection of high-risk cases.