Abstract | BACKGROUND: METHODS: In this population-based retrospective observational study, data on all PLWMS, vaccination, SARS-CoV-2 tests, hospitalization, and deaths were collected in Isfahan, Iran between February 9, 2021, and November 4, 2021. We estimated the hazard ratio between vaccinated (partially and fully) and unvaccinated groups using the Andersen-Gill extension of the Cox proportional hazards model. We also performed Cox proportional hazards analysis to identify risk factors for breakthrough infection and COVID-19-related hospitalization in fully-immunized group. RESULTS: Of the 9869 PLWMS, 1368 were in partially-vaccinated group, 4107 were in the fully-vaccinated group, and 3794 were in the unvaccinated group. In the partially-vaccinated group, the estimated VE against COVID-19 infection was 39.3% (16%, 56.1%), hospitalization was 64.9% (1.3%, 87.5%), and mortality was 92.7% (88.8%, 100%). The respective results for the fully-vaccinated group were 63.9% (56%, 70.3%), 75.7% (57.5%, 86.1%), and 100%. Progressive MS was independently associated with a greater risk of breakthrough infection (HR=1.952, 95%CI: 1.174-3.246, p = 0.010). Older adults (≥50 years vs. 18-49 years, HR=3.115, 95%CI: 1.145-8.470, p = 0.026) and those on rituximab (HR=7.584; 95% CI: 1.864-30.854; p = 0.005) were at an increased risk of COVID-19-related hospitalization. CONCLUSION: This study showed that two doses of the BBIBP-CorV vaccine can effectively prevent COVID-19 infection and hospitalization among PLWMS. Old PLWMS and those who treating with rituximab are at increased risk of hospitalization after receiving two doses of the vaccine.
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Authors | Mahdi Barzegar, Amirreza Manteghinejad, Alireza Afshari-Safavi, Omid Mirmosayyeb, Maryam Nasirian, Sara Bagherieh, Shahrbanoo Mazaheri, Maryam Rahimi, Aram Zabeti, Shaghayegh Haghjooy Javanmard, Vahid Shaygannejad |
Journal | Multiple sclerosis and related disorders
(Mult Scler Relat Disord)
Vol. 71
Pg. 104548
(Mar 2023)
ISSN: 2211-0356 [Electronic] Netherlands |
PMID | 36827877
(Publication Type: Observational Study, Journal Article)
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Copyright | Copyright © 2023. Published by Elsevier B.V. |
Chemical References |
- BIBP COVID-19 vaccine
- RNA, Viral
- Rituximab
- Vaccines
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Topics |
- Humans
- Aged
- COVID-19
(prevention & control)
- RNA, Viral
- SARS-CoV-2
- Multiple Sclerosis
(complications)
- Rituximab
- Vaccines
- Breakthrough Infections
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