[A Case Report of Hepatic Angiosarcoma Developed against the Background of Hepatic Hemochromatosis].

Abstract

A 35-year-old man who had fever and stomachache was referred to our hospital. He underwent surgery and chemoradiotherapy for neuroblastoma as a child and subsequently developed leukemia. Frequent blood transfusions and bone marrow transplants were performed due to anemia. Abdominal contrast CT scan and contrast MRI showed tumorous lesions with a diameter of 60×42 mm in liver S6, and a tendency to increase in a short term. There was also hemochromatosis in the liver. We considered it a malignant tumor and performed a right lobectomy. Pathological examination diagnosed the tumor hepatic angiosarcoma. The postoperative course was fine and he was discharged without complications. But multiple liver metastases appeared 6 months after surgery. We performed chemotherapy but he passed away 10 months after surgery. Hepatic angiosarcoma is a rare disease among liver malignancies and has a very poor prognosis. As for the cause of hepatic angiosarcoma, many of them are unknown, but chronic exposures such as vinyl monomers have been reported in some cases. Hemochromatosis has been reported as a background factor for malignant tumors such as hepatocellular carcinoma. In this case it is possible that it contributed to the development of hepatic angiosarcoma.

• Authors: Tomohiro Kako, Yoichi Matsuo, Hiroyuki Kato, Tomokatsu Kato, Yuichi Hayashi, Hiroyuki Imafuji, Kenta Saito, Tomoya Shamoto, Ken Tsuboi, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Akira Mitsui, Masahiro Kimura, Shuji Takiguchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 50 Issue 2 Pg. 242-244 (Feb 2023) ISSN: 0385-0684 [Print] Japan
• PMID: 36807185 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Male
• Child
• Humans
• Adult
• Hemochromatosis (complications)
• Hemangiosarcoma (surgery)
• Liver Neoplasms (surgery)
• Carcinoma, Hepatocellular (complications)