Abstract | PURPOSE: METHODS: Records of 7759 adult patients who received general anesthesia with remifentanil were reviewed. The patients were assessed for the incidence and severity of PONV. Multiple logistic regression was used to identify risk factors for PONV. A nomogram was established to predict PONV after same-day operations. FINDINGS: Of 7759 patients, 2317 (29.9%) experienced PONV. In multiple logistic regression analysis, female sex, nonsmoker status, history of motion sickness or nausea, high body mass index (BMI), long surgical duration, laparoscopic procedure, and preoperative analgesic intake within 30 days were independent risk factors for PONV. No correlation was found between the severity of PONV and remifentanil exposure (odds ratio = 1.018; 95% CI, 0.861-1.204; P = 0.834) or remifentanil dose (odds ratio = 1.294; 95% CI, 0.760-2.205; P = 0.343). For the nomogram, which involved sex, laparoscopic procedure, BMI, history of nausea or motion sickness, and analgesic intake within 30 days, the receiver operating characteristic analysis revealed that the AUC values in the training and validation cohorts were 0.81 and 0.83, respectively. IMPLICATIONS: Predictors for PONV in same- day surgery include female sex, nonsmoker, history of motion sickness or nausea, high BMI, surgical duration >1 hour, laparoscopic procedure, and preoperative analgesic intake within 30 days. A new predictive model is feasible for predicting the incidence of PONV based on the preoperative and intraoperative predictors.
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Authors | Lili Qiu, Jinxia Cai, Aishuang Mei, Xiaofeng Wang, Zijun Zhou, Jiehao Sun |
Journal | Clinical therapeutics
(Clin Ther)
Vol. 45
Issue 3
Pg. 210-217
(03 2023)
ISSN: 1879-114X [Electronic] United States |
PMID | 36781358
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Humans
- Female
- Postoperative Nausea and Vomiting
(epidemiology)
- Retrospective Studies
- Remifentanil
- Ambulatory Surgical Procedures
- Risk Factors
- Motion Sickness
- Antiemetics
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