The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA.

Abstract

BACKGROUND:

Common chronic infections induced low-grade inflammation has been correlated with atherosclerosis as supported by strong evidence. The balance between pro-and anti-inflammatory factors was exploited to elucidate the effects of chronic periodontitis on diabetes-associated atherosclerosis.

METHODS:

Study subjects encompassed 30 SPF male rats randomly divided into four groups: A group (NC), B group (T2DM), C group (CP), D group (DM + CP). After developing the model, blood samples were collected from the angular vein analyze serum APN, hs-CRP, and blood lipid. the carotid artery was isolated for HE staining.

RESULT:

Compared with group A, the serum APN in group B, C and D decreased gradually with the progression of the disease. Serum hs-CRP in group B, C and D was significantly increased. At T3, T4 and T5 in group B, C and D, APN/hs-CRP significantly decreased. TC, LDL and TG significantly increased in group B, D; HDL significantly decreased in group C. Carotid artery HE staining showed: compared with group A, different degrees of endothelial defect, destruction of elastic fibers in the middle membrane, disorder of smooth muscle arrangement, and partial dissolution 、 fragmentation and Calcium salt deposition necrosis occurred in group B, C and D.

CONCLUSION:

Enhanced systemic inflammation, decreased adiponectin level, and disorganized lipid metabolism with or without type 2 diabetes attributed to local inflammation of periodontitis can result in an imbalance of pro-inflammatory and anti-inflammatory effects. Therefore, it's more meaningful to predict the progression of DAA with anti-inflammatory/pro-inflammatory variation.

• Authors: Rui Cheng, Xiaojiang Xu, Shurong Yang, Zhongqian Mi, Yong Zhao, Chong Wang, Xuexue Shi, Jinhua Gao, Feiyan Yu, Xiuyun Ren
• Journal: BMC oral health (BMC Oral Health) Vol. 23 Issue 1 Pg. 85 (02 10 2023) ISSN: 1472-6831 [Electronic] England
• PMID: 36765308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023. The Author(s).

Chemical References

• C-Reactive Protein

Topics

• Male
• Rats
• Animals
• C-Reactive Protein (metabolism)
• Diabetes Mellitus, Type 2
• Atherosclerosis
• Inflammation
• Chronic Periodontitis (complications)