Abstract | BACKGROUND: METHODS: We established a reliable method for measuring lysophosphatidylcholine (LPC), a precursor of lysophosphatidic acids which are known as being pain initiators, using a liquid chromatography-tandem mass spectrometry method, and measured the LPC concentrations in the cerebrospinal fluid (CSF) in patients with SCS (SCS group; n = 76), patients with neuropathic pain caused by non-SCS diseases (Others group; n = 49), and control subjects without pain (control group; n = 92). RESULTS: Both within-run and between-run CV(%) were almost < 10 %, suggesting an enough performance for clinical introduction. The CSF concentrations of LPC (16:0) and LPC (18:0) were higher in the SCS group than those in the Control or Others group; the concentrations of LPC (18:1), LPC (18:2), LPC (20:4), LPC (22:6) levels were higher in the SCS group than those in the control or others group, but they were also higher in the Others group than those in the control group. The areas under the curve in the ROC curve analyses of LPC (18:1) for discriminating between the SCS and control groups, others and control groups, and SCS and others groups were 0.994, 0.860, and 0.869, respectively. CONCLUSIONS: LPC measurement in the CSF is useful for the differential diagnosis of neuropathic pain, especially for surgical decision-making, which is expected for clinical introduction.
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Authors | Makoto Kurano, Masahiko Sumitani, Yoshiyuki Akiyama, Masaki Yamada, Daiki Fujimura, Satoshi Yamaki, Kuniyuki Kano, Junken Aoki, Kentaro Hayakawa, Takuya Takahashi, Takashi Hirai, Atsushi Okawa, Haruki Kume, Toru Ogata, Sakae Tanaka, Hirotaka Chikuda, Yutaka Yatomi |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 541
Pg. 117249
(Feb 15 2023)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 36764506
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Lysophosphatidylcholines
- Lysophospholipids
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Topics |
- Humans
- Lysophosphatidylcholines
- Diagnosis, Differential
- Neuralgia
(cerebrospinal fluid)
- Lysophospholipids
- Clinical Laboratory Techniques
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