The prognostic value of caveolin-1 levels in ischemic stroke patients after mechanical thrombectomy.

Abstract

BACKGROUND AND PURPOSE:

The impact of serum caveolin-1 (Cav-1) on clinical outcomes in patients after mechanical thrombectomy (MT) is unclear. We aimed to investigate the association between serum cav-1 levels and the 3-month functional outcome.

METHODS:

We prospectively enrolled and analyzed patients with an anterior circulation large vessel occlusion who underwent MT. Serum cav-1 concentrations were tested after admission. The primary outcome was a 90-day modified Rankin Scale score of 3-6.

RESULTS:

Of the 237 recruited patients (mean age, 69.7 ± 12.1 years; 152 male), 131 (55.3%) experienced a 90-day poor outcome. After adjustment for demographic characteristics and other covariates, patients with higher serum Cav-1 levels had a reduced risk of poor outcome at 3 months (Per 1-standard deviation increase; odd ratios [OR], 0.59; 95% confidence interval [CI], 0.39 - 0.89, P = 0.013). Elevated Cav-1 concentrations (Per 1-standard deviation increase; OR, 0.59; 95% CI, 0.40 - 0.88, P = 0.011) were significantly associated with a favorable shift in modified Rankin Scale score distribution. Similar results were confirmed when the Cav-1 levels were analyzed as a categorical variable. Furthermore, the restricted cubic spline showed a linear association between Cav-1 levels and 90-day poor outcome (P = 0.032 for linearity).

CONCLUSIONS:

Increased serum Cav-1 levels were associated with improved prognosis at 3 months in ischemic stroke patients after MT, suggesting that Cav-1 may be a potential prognostic biomarker for ischemic stroke after reperfusion therapy.

• Authors: Qingguang Wang, Haiming Cao, Yan E, Siyu Wang, Shuaiyu Chen, Huiwen Lian, Meng Wang, Junshan Zhou, Yi Xie, Xiaohao Zhang
• Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 44 Issue 6 Pg. 2081-2086 (Jun 2023) ISSN: 1590-3478 [Electronic] Italy
• PMID: 36746844 (Publication Type: Journal Article)
• Copyright: © 2023. Fondazione Società Italiana di Neurologia.

Chemical References

• Caveolin 1

Topics

• Aged
• Aged, 80 and over
• Humans
• Male
• Middle Aged
• Brain Ischemia (surgery)
• Caveolin 1
• Ischemic Stroke (etiology)
• Prognosis
• Retrospective Studies
• Stroke (surgery)
• Thrombectomy
• Treatment Outcome