Abstract | OBJECTIVES: METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in this meta-analysis. Up to the 2nd of July 2022 a search was conducted using five databases: PubMed, Embase, Scopus, ProQuest, and Web of Science. The methodological standards for the epidemiological research scale were used to assess the quality of the included articles, and Stata software was used to synthesize the meta-analysis. RESULTS: We considered 13 of the 615 studies which included 1005 HNSCC patients. High expression of CCR7 increased the pooled odds ratio (OR) of advanced stage, tumor size, metastasis and recurrence by 2.82 [95% confidence interval (CI) 1.84 to 4.33], 2.48 (95% CI 1.68, to 3.67), 3.57, 95% CI 2.25 to 5.05) and 3.93 (95% CI 2.03 to 7.64), respectively. High CCR7 reduced overall patient survival [hazard ratio 2.62 (95% CI 1.59 to 4.32)]. CONCLUSION: This study showed that high expression of CCR7 in HNSCC tumors was significantly associated with worse clinicopathological and survival outcomes, suggesting that CCR7 and its pathway could be potential therapeutic strategies for HNSCC.
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Authors | Ibrahim Elmakaty, Basel Elsayed, Mohamed Elmarasi, Omar Kujan, Mohammed Imad Malki |
Journal | Expert review of anticancer therapy
(Expert Rev Anticancer Ther)
Vol. 23
Issue 4
Pg. 443-453
(04 2023)
ISSN: 1744-8328 [Electronic] England |
PMID | 36744447
(Publication Type: Meta-Analysis, Systematic Review, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, CCR7
- CCR7 protein, human
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Topics |
- Humans
- Squamous Cell Carcinoma of Head and Neck
- Receptors, CCR7
- Prognosis
- Proportional Hazards Models
- Head and Neck Neoplasms
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