Ubrogepant and rimegepant: systematic review, meta-analysis, and meta-regression of clinical studies.

Abstract

OBJECTIVES:

This study aimed at providing pooled estimates of the incidence of adverse drug reactions (ADRs) of ubrogepant and rimegepant and to use meta-regression to identify correlations between the occurrence of selected ADRs, socio-demographic, and clinical characteristics from data published in clinical studies.

METHODS:

Ovid MEDLINE (up to 03/02/2022) was searched along with the references listed in the reviews identified with the research query. Random intercept and slope logistic regression models were used to estimate the logit transformation of the pooled incidence. To examine how selected clinical and socio-demographic characteristics correlated with the pooled incidence rates, we performed random-effects meta-regression.

RESULTS:

Significant heterogeneity of incidence estimates was observed in clinical studies along with correlations between ADRs and the sociodemographic and clinical characteristics of patients exposed to ubrogepant. In particular, we observed a correlation between ubrogepant dosage and muscle strain and between Body Mass Index (BMI) and liver function values. For rimegepant, significant correlations were observed between age and infections and having aura symptoms at baseline and nausea/dizziness/diarrhea/muscle strain.

CONCLUSION:

This study provided pooled incidence estimates of ubrogepant and rimegepant's ADRs and highlighted new safety aspects of the pharmacological treatment with ubrogepants and rimigepants from correlations obtained from the meta-regression.

• Authors: Guojun Dong, Naoko Adachi Kjærgaard, Saeed Shakibfar, Maurizio Sessa
• Journal: Expert opinion on drug safety (Expert Opin Drug Saf) Vol. 22 Issue 1 Pg. 59-70 (Jan 2023) ISSN: 1744-764X [Electronic] England
• PMID: 36737057 (Publication Type: Systematic Review, Meta-Analysis, Journal Article)

Chemical References

• ubrogepant
• rimegepant sulfate
• Pyridines
• Piperidines
• Pyrroles

Topics

• Humans
• Pyridines (adverse effects)
• Piperidines
• Pyrroles (adverse effects)
• Drug-Related Side Effects and Adverse Reactions