[A Case of Sigmoid Colon Cancer with Bladder Invasion That Could Be Treated with Neoadjuvant Chemotherapy to Preserve the Bladder].

Abstract

The patient was male, 50s. He visited his local doctor with complaints of hematochezia and hematuria. He underwent colonoscopy, which revealed a circumferential lesion in the sigmoid colon, and he was referred to our department for further examination and treatment. A urinalysis at the time of admission revealed leukocytes(3+)and bacteria(2+), suggesting that the sigmoid colon cancer was invading the bladder. The urologist performed cystoscopy, which showed internal invasion of the bladder, and at this point, including the CT findings, it was needed that a combined bladder resection was necessary. We decided to undergo neoadjuvant chemotherapy(NAC)with the possibility of bladder preservation. FOLFOXIRI plus bevacizumab was selected as the regimen, and a total of 6 courses were performed. After NAC, the effect was judged PR. The patient underwent laparoscopy-assisted resection of the sigmoid colon and partial resection of the bladder wall. The pathological diagnosis was ypStage Ⅱc. Postoperatively, the patient received 6 courses of FOLFOX as adjuvant chemotherapy. Currently, about 8 months after surgery, no recurrence has been observed.

• Authors: Taishi Hata, Go Shinke, Shinsuke Katsuyama, Ryo Ikeshima, Kenji Kawai, Masayuki Hiraki, Yoshiteru Katsura, Yoshiaki Ohmura, Keijiro Sugimura, Toru Masuzawa, Yutaka Takeda, Gaku Kawabata, Kohei Murata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 49 Issue 13 Pg. 1613-1615 (Dec 2022) ISSN: 0385-0684 [Print] Japan
• PMID: 36733152 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Humans
• Male
• Urinary Bladder (surgery)
• Sigmoid Neoplasms (drug therapy, surgery, pathology)
• Neoadjuvant Therapy
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Colon, Sigmoid (pathology)