[Two Cases of Stage Ⅳ Colorectal Cancer with Long-Term Survival following Single-Agent Chemotherapy with Capecitabine-A Case Reports].

Abstract

We experienced 2 cases of Stage Ⅳ colorectal cancer obtained long-term survival by chemotherapy with only capecitabine. Case 1: Seventy-one-years-old male was performed open sigmoid colectomy, D2 dissection for sigmoid colon cancer. Pathological diagnosis was pT4aN2aM0, pStage Ⅲc. Capecitabine plus oxaliplatin(CAPOX)was performed as adjuvant chemotherapy for 6 months consequently. Two-years after operation, peritoneal dissemination was found, and CAPOX plus bevacizumab(BEV)was started. Due to appearance of renal disfunction and proteinuria, only capecitabine was continued. Since then, 60 months have been passed without disease progression. Case 2: Seventy-six-years-old female was diagnosed as ascending colon cancer with multiple lung metastases. She had initially given systematic chemotherapy with CAPOX plus BEV. Grade 2 adverse effect(numbness and diarrhea)appeared, then the chemotherapy was discontinued. Seven months later, bowel obstruction due to tumor growth was appeared, and open right-hemi colectomy, with D3 dissection was performed for relief of symptoms. Pathological diagnosis was pT3N1bM1a, pStage Ⅳa. With her request, chemotherapy was performed with only capecitabine. Although lung metastasis was slowly progressed, for 72 months she has maintained good general condition since the chemotherapy with only capecitabine was started.

• Authors: Kotaro Suda, Tsuyoshi Chiku, Minami Fukuyama, Kimio Shinoda, Hirotaka Hashiba, Wataru Sano, Katsuhiko Ando
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 49 Issue 13 Pg. 1882-1884 (Dec 2022) ISSN: 0385-0684 [Print] Japan
• PMID: 36733031 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Capecitabine
• Oxaliplatin
• Bevacizumab
• Fluorouracil

Topics

• Humans
• Male
• Female
• Aged
• Capecitabine (adverse effects)
• Colorectal Neoplasms (drug therapy)
• Colonic Neoplasms (surgery)
• Oxaliplatin (adverse effects)
• Bevacizumab (therapeutic use)
• Chemotherapy, Adjuvant (adverse effects)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Fluorouracil (adverse effects)