Lung cancer (LC) remains the leading cause of
cancer-related deaths worldwide, with extremely high morbidity and mortality rates.
Non-small cell lung cancer (NSCLC) is the most critical type of LC. It seriously threatens the life and health of patients because of its early
metastasis, late clinical symptoms, limited early screening methods, and poor treatment outcomes. Non-coding RNAs (ncRNAs), including
microRNAs (
miRNAs), long non-coding RNAs (lncRNAs), and
circular RNAs (
circRNAs), participate in cell proliferation,
metastasis, and chemoresistance. Several previous studies have proven that ncRNAs are vital regulators of
tumorigenesis. Ubiquitination plays the most crucial role in
protein post-translational modification (PTM). Deubiquitination and ubiquitination form a homeostasis. In summary, ubiquitination and deubiquitination play essential roles in mediating the degradation or overexpression of a range of crucial
proteins in various
cancers. A growing number of researchers have found that interactions between ncRNAs and ubiquitination (or deubiquitination) play a crucial role in NSCLC. This review presents several typical examples of the important effects of ncRNAs and ubiquitination (or deubiquitination) in NSCLC, aiming to provide more creative ideas for exploring the diagnosis and treatment of NSCLC.