It is highly desirable to develop novel multifunctional
wound dressing materials capable of delivering active molecules capable of resolving
bacterial infections and replenishment of appropriate
growth factors for bacteria-infected wound healing.
Polysaccharides have numerous biomedical benefits and have been widely used to construct
biomaterial scaffolds. Herein, multifunctional
chitosan/
alginate hydrogel decorated with β-
cyclodextrin (β-CD) modified
polydopamine (PDA)-bioactive glass (BG) nanoparticles (NPs) integrating photothermal performance and
nitric-oxide release activities for the treatment of bacterially infected
wounds is presented. As the NO precursor N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine (BNN6) encapsulated into the hydrophobic cavity of β-CD on the PDA-coated BG NPs, the resultant NO@CD-PDA/BG NPs, are imparted with the feature of NIR triggered NO release and desired PTT/NO synergetic antibacterial effects. Furthermore, the release of NO, Ca, and Si
ions from the NO@CD-PDA/BG NPs, has the benefit of regulating
inflammation, promoting fibroblast proliferation, and stimulating angiogenesis. Besides, the
chitosan/
alginate hydrogel scaffolds provided a suitable microenvironment to accelerate wound healing. By applying the multifunctional
chitosan/
alginate nanocomposite hydrogel to S. aureus-infected full-thickness skin defect mouse model, the authors demonstrated that
chitosan/
alginate nanocomposite hydrogel has multiple functions in preventing
bacterial infections, accelerating angiogenesis and
wound regeneration, indicating promising application in wound healing.