Abstract | Introduction: Methods: Results: Three studies were identified as providing relevant information on antiemetic prophylaxis with initiation of injectable apomorphine. The first study demonstrated that nausea was significantly more common in patients who received 3-days of trimethobenzamide pretreatment compared with those who did not, while the primary endpoint of second study found no significant effect on the binary incidence of nausea and/or vomiting on Day 1 of apomorphine treatment. In the third study, which used a slow titration scheme for apomorphine, transient nausea was reported in just 23.1% of the antiemetic nonusers. Conclusions: Based on the reviewed trials and our clinical experience, we suggest that subcutaneous apomorphine therapy can be initiated using a slow titration scheme without antiemetic pretreatment.
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Authors | Stuart H Isaacson, Richard B Dewey Jr, Rajesh Pahwa, Daniel E Kremens |
Journal | Clinical parkinsonism & related disorders
(Clin Park Relat Disord)
Vol. 8
Pg. 100174
( 2023)
ISSN: 2590-1125 [Electronic] England |
PMID | 36691604
(Publication Type: Journal Article)
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Copyright | © 2022 The Authors. |