Effect of intravenous iron on endogenous erythropoietin and FGF-23 secretion in patients with chronic kidney disease.

Abstract

INTRODUCTION:

It has been observed that intravenous iron administration may suppress endogenous production of erythropoietin (EPO). We postulate that this effect may be mediated by increased FGF-23 secretion.

AIM OF THE STUDY:

To evaluate the short-term effect of intravenous iron sucrose administration on endogenous EPO secretion in patients with chronic kidney disease (CKD).

MATERIALS AND METHODS:

The cohort comprised 35 nondialysis patients with CKD stages 3-5. All received 100 mg of intravenous iron (III)-hydroxide sucrose complex daily for five consecutive days. Plasma EPO, iFGF-23, cFGF-23, PTH, bone alkaline phosphatase (BAP), phosphorus (PO4), calcium (Ca), and high-sensitive C-reactive protein (CRP) were measured before, and two hours after, the first and third iron infusions, and after completing iron therapy.

RESULTS:

EPO concentration at the end of iron treatment was significantly lower than two hours after the first iron infusion (p = 0.0003) and before the third dose (p = 0.0006) (12.6 [10.2, 41.4] mIU/mL. vs. 30.9 [15.9, 54.2] mIU/mL and 33.4 [15.4, 56.7] mIU/mL, respectively). Conversely, plasma iFGF-23 was significantly higher before the third dose (61.1 [18.6, 420.1 4] pg/mL; p = 0.025) and after the course of treatment (92.1 [28.4, 878.1] pg/mL; p = 0.004) compared to pretreatment value (48.4 [16.2, 420] pg/mL). cFGF-23 concentration was significantly lower than baseline after the first iron dose (491.8 [257.7, 1086.3] vs. 339.2 [75.4, 951.2] RU/mL; p = 0.005) and after treatment (398.7 [90.4, 1022.3] RU/mL; p = 0.025). No significant linear correlation was found between changes in plasma EPO and FGF-23.

CONCLUSIONS:

Although intravenous iron therapy causes parallel increase of FGF-23 and supression of endogenous EPO, these two effects seem to be independent.

• Authors: Katarzyna Muras-Szwedziak, Ewa Pawłowicz-Szlarska, Michał Nowicki
• Journal: Renal failure (Ren Fail) Vol. 45 Issue 1 Pg. 2164305 (Dec 2023) ISSN: 1525-6049 [Electronic] England
• PMID: 36688811 (Publication Type: Journal Article)

Chemical References

• Iron
• Erythropoietin
• Ferric Oxide, Saccharated
• Epoetin Alfa

Topics

• Humans
• Iron (metabolism)
• Renal Insufficiency, Chronic
• Erythropoietin
• Ferric Oxide, Saccharated
• Epoetin Alfa