Associations of cord blood meta-inflammation and vitamin D with neurodevelopmental delay: A prospective birth cohort study in China.

Abstract

Aim:

To estimate the associations of cord meta-inflammatory markers with neurodevelopment, including the potential impact of cord blood vitamin D levels.

Method:

The prospective cohort study comprised 7198 participants based on the Maternal & Infants Health in Hefei study. Cord blood C-peptide, high-sensitive C-reactive protein (hsCRP), high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglycerides and 25(OH)D levels were measured. The Gesell Developmental Schedules were used to assess neurodevelopmental outcomes in offspring.

Results:

After adjusting potential confounders, per quartile increase in cord blood 25(OH)D concentrations was associated with a decreased risk of neurodevelopmental delay [hazard ratios (HR) 0.65 (95% CI 0.57, 0.74)]. Conversely, significant positive associations with cord blood serum C-peptide levels above the 90th percentile [HR 2.38 (95% CI 1.81, 3.13)] and higher levels of cord hsCRP (per quartile increase) [HR 1.18 (95% CI 1.01, 1.37)] with neurodevelopmental delay were observed. These associations could vary by quartiles of cord blood 25(OH)D levels: the adjusted HRs in neurodevelopmental delay comparing children with vs without hyperinsulinemia were 1.28 (95% CI: 1.03, 1.59) for quartiles 1 (lowest), and 1.06 (95% CI: 0.78, 1.44) for quartile 4 (highest).

Conclusions:

Immune activation and metabolic abnormalities in fetal circulation were associated with neurodevelopmental delay in offspring, which could be attenuated by higher cord blood 25(OH)D levels in a dose-response manner.

• Authors: Peng Wang, Lin Wu, Wan-Jun Yin, Rui-Xue Tao, Ying Zhang, Pei-Pei Li, Xiao-Min Jiang, Zi-Yu Shao, Peng Zhu
• Journal: Frontiers in immunology (Front Immunol) Vol. 13 Pg. 1078340 ( 2022) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 36685522 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 Wang, Wu, Yin, Tao, Zhang, Li, Jiang, Shao and Zhu.

Chemical References

• Vitamin D
• C-Reactive Protein
• C-Peptide
• Vitamins
• Cholesterol

Topics

• Infant
• Child
• Humans
• Vitamin D
• Cohort Studies
• Prospective Studies
• Fetal Blood
• Vitamin D Deficiency (complications)
• C-Reactive Protein
• C-Peptide
• Vitamins
• Inflammation (complications)
• Cholesterol