Abstract | OBJECTIVES: DESIGN AND METHODS: Twenty-one patients diagnosed with acromegaly and 12 patients with adult GH deficiency (GHD) were studied at diagnosis and after treatment. A reference group of 12 subjects was included. Each study day comprised assessment of body composition with dual-energy X-ray absorptiometry, ectopic lipid deposition in the liver by MR spectroscopy, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). RESULTS: Disease control of acromegaly decreased lean body mass (LBM) (P < .000) and increased the percentage of total body fat (TBF) (P < .000). GH replacement increased LBM in the GHD patients (P = .007) and decreased the percentage of TBF (P = .010). The intrahepatic lipid (IHL) content increased after disease control in acromegaly (P = .004), whereas IHL did not change significantly after GH replacement in GHD (P = .34). Insulin resistance (HOMA-IR) improved after disease control of acromegaly (P < .000) and remained unaltered after GH replacement in the GHD patients ( P = .829). CONCLUSIONS:
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Authors | Mai C Arlien-Søborg, Michael Alle Madsen, Jakob Dal, Thomas Krusenstjerna-Hafstrøm, Steffen Ringgaard, Nickolaj Skou, Morten Høgild, Jens Otto Lunde Jørgensen |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 188
Issue 1
(Jan 10 2023)
ISSN: 1479-683X [Electronic] England |
PMID | 36651164
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2023. Published by Oxford University Press on behalf of (ESE) European Society of Endocrinology. All rights reserved. For permissions, please e-mail: [email protected]. |
Chemical References |
- Growth Hormone
- Human Growth Hormone
- Insulin-Like Growth Factor I
- Lipids
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Topics |
- Adult
- Humans
- Acromegaly
(drug therapy, complications)
- Body Composition
- Growth Hormone
(deficiency)
- Human Growth Hormone
(therapeutic use)
- Insulin Resistance
- Insulin-Like Growth Factor I
(metabolism)
- Lipids
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