Investigating the effect of ARHGEF10L gene on tumor growth in gastric cancer in a nude mouse model using quantitative MRI parameters.

Abstract

Background:

The quantitative magnetic resonance imaging (MRI) parameters were initially used in the study of central nervous system diseases and has since been widely used in the diagnosis of breast, liver, rectum, and prostate diseases. In our study, we aimed to evaluate the effect of ARHGEF10L gene on tumor growth in gastric cancer in nude mice using quantitative MRI parameters.

Subjects and Methods:

A nude mice model of gastric cancer was established, and the mice were divided into a control group and an shARHGEF10L group (N = 10). T2-fs and intravoxel incoherent motions (IVIM) imaging were performed in the mice coil with a 3.0 T MR system. The differences in quantitative parameters (apparent diffusion coefficient [ADC], D, D *, f values) were compared between both groups, and the effect of ARHGEF10L expression on tumor growth in tumor-bearing mice was investigated. The data were analyzed using Statistical Package for the Social Sciences (SPSS) 17.0 software package.

Results:

The ADC and D values of tumor imaging in the shARHGEF10L group were higher than those in the control group, and the differences were statistically significant. There was no significant difference in the D* or F values between both groups.

Conclusions:

The ADC and D values of the quantitative IVIM imaging parameters can be used to effectively assess the growth of gastric cancer in nude mice, suggesting that ARHGEF10L may promote the growth of tumor cells.

• Authors: Junyi Tang, Xuping Zhang, Huan Chang, Dawei Wang
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 18 Issue 7 Pg. 1926-1930 (Dec 2022) ISSN: 1998-4138 [Electronic] India
• PMID: 36647951 (Publication Type: Journal Article)

Topics

• Animals
• Male
• Mice
• Diffusion Magnetic Resonance Imaging (methods)
• Mice, Nude
• Rectum (pathology)
• Stomach Neoplasms (diagnostic imaging, genetics, pathology)