N6-methyladenine RNA Methylation Epigenetic Modification and Kidney Diseases.

Abstract

RNA methylation modification is a rapidly developing field in epigenetics. N6-methyladensine (m6A) is the most common internal modification in eukaryotic mRNA. m6A group regulates RNA splicing, stability, translocation, and translation. Enzymes catalyzing this process were termed as writers, erasers, and readers. Recent studies have focused on exploring the role of RNA methylation in human diseases. RNA methylation modifications, particularly m6A, play important roles in the pathogenesis of kidney diseases. In this review, we provide a brief description of m6A and summarize the impact of m6A on acute and chronic kidney disease (CKD) and possible future study directions for this research.

• Authors: Junjun Luan, Jeffrey B Kopp, Hua Zhou
• Journal: Kidney international reports (Kidney Int Rep) Vol. 8 Issue 1 Pg. 36-50 (Jan 2023) ISSN: 2468-0249 [Electronic] United States
• PMID: 36644366 (Publication Type: Journal Article, Review)
• Copyright: © 2022 Published by Elsevier Inc. on behalf of the International Society of Nephrology.