Objective and Subjective Sleep Patterns in Adults With Maturity-Onset Diabetes of the Young (MODY).

Abstract

OBJECTIVE:

To examine sleep patterns in adults with maturity-onset diabetes of the young (MODY).

RESEARCH DESIGN AND METHODS:

Adults with glucokinase (GCK)-MODY and transcription factor (TF)-related MODY (HNF1A, HNF1B, HNF4A) were recruited (n = 24; age 46.0 years, 79% women, BMI 24.7 kg/m2) from The University of Chicago's Monogenic Diabetes Registry. Sleep patterns were assessed by 2-week wrist actigraphy (total 315 nights), one night of a home sleep apnea test, and validated surveys.

RESULTS:

Overall, compared with established criteria, 29% of participants had sleep latency ≥15 min, 38% had sleep efficiency ≤85%, 46% had wake after sleep onset >40 min, all indicating poor objective sleep quality. Among all participants, 54% had a sleep duration below the recommended minimum of 7 h, 88% reported poor sleep quality, 58% had obstructive sleep apnea, and 71% reported insomnia. Compared with GCK-MODY, participants with TF-related MODY had poorer objective sleep quality and increased night-to-night variability in sleep patterns.

CONCLUSIONS:

Sleep disturbances appear to be common in adults with MODY despite absent traditional risk factors for sleep disorders. Future research investigating the sleep-diabetes relationship is warranted in this population.

• Authors: Marilyn Arosemena, Maria V Salguero, Rochelle N Naylor, Kristen Wroblewski, Esra Tasali, Louis H Philipson
• Journal: Diabetes care (Diabetes Care) Vol. 46 Issue 3 Pg. 608-612 (03 01 2023) ISSN: 1935-5548 [Electronic] United States
• PMID: 36637968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © 2023 by the American Diabetes Association.

Chemical References

• Glucokinase
• Hepatocyte Nuclear Factor 1-alpha

Topics

• Female
• Humans
• Male
• Middle Aged
• Diabetes Mellitus, Type 2 (complications, epidemiology)
• Glucokinase (genetics)
• Hepatocyte Nuclear Factor 1-alpha (genetics)
• Mutation
• Risk Factors
• Sleep
• Sleep Disorders, Intrinsic (etiology)