The
oral mucositis is a mucosal alteration that usually arises from oncological treatments, such as
chemotherapy, and it is characterized as an inflammatory process. The aim of this study is to demonstrate the chromatographic constitution of Andiroba oil, comparing and evaluating Andiroba oil and
laser scarring efficiency in treatments of
oral mucositis in hamsters. These animals were submitted to
5-Fluorouracil. A total of 122 animals were used, randomized and divided into the following groups: (a) positive control; (b)
laser associated to andiroba oil; (c)
laser; (d) andiroba oil; (e) negative control; (f)
cyclophosphamide (genotoxicity control). The induction of
oral mucositis occurred by the administration of intraperitoneal Fluorouracila (60 mg/kg) and
trauma to the mucosa. The
laser protocol was performed once a day and the andiroba oil applied 3 times a day (1,5 ml/day). The mucosae were photographed and removed for clinical and histopathological analysis on day 4, 8, 12 and 15. The analysis was based in OM severity, in specific scoring for the clinical and histopathological aspect. Toxicity was evaluated on day 15 using comet assay and it was performed by variant DNA damage parameters. The data were analysed using analysis of variance (ANOVA) Tukey post-test and Kruskal-Wallis Dunn post-test. The "andiroba oil" and "
laser" groups presented better results when compared to the control groups and the treatment associations. The andiroba oil presented the best
scarring results, even considering its efficiency proximity to the
laser treatment. Andiroba and
laser, separately, did not present genotoxicity, however their association evidences damage to
DNA.