Abstract |
Vancomycin is recommended for the treatment of skin and soft tissue infections (SSTI) and bone and joint infections (BJI). However, a detailed investigation of the pharmacokinetic profile and optimal dosing regimens of vancomycin in pediatric patients with SSTI and BJI is lacking. We successfully developed a new PopPK model of vancomycin in this population by using scavenged blood samples with the typical values for clearance (CL) of 0.14 L/h/kg and volume of distribution (V) of 0.5 L/kg. Body weight was confirmed as the significant covariate on CL and V. The optimal dosing regimens of 75 mg/kg/day and 80 mg/kg/day were recommended for this specific population.
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Authors | Meng Lv, Ping Yang, Shengnan Zhang, Lingling Wang, Keming Sun, Libo Zhao |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 67
Issue 1
Pg. e0162422
(01 24 2023)
ISSN: 1098-6596 [Electronic] United States |
PMID | 36622172
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vancomycin
- Anti-Bacterial Agents
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Topics |
- Humans
- Child
- Vancomycin
- Anti-Bacterial Agents
(pharmacokinetics)
- Soft Tissue Infections
(drug therapy)
- Models, Biological
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