Abstract | BACKGROUND:
Retinoblastoma, the most common pediatric intraocular malignancy, can develop during embryogenesis, with most children being diagnosed at 3-4 years of age. Multimodal therapies are typically associated with high levels of cytotoxicity and side effects. Therefore, the development of novel treatments with minimal side effects is crucial. Magnolol has a significant anti- tumor effect on various cancers. However, its antitumor effect on retinoblastoma remains unclear. PURPOSE: METHODS: RESULTS:
Magnolol increased E-cadherin levels and reduced the activation of the EMT signaling pathway, EMT, tumor growth, metastasis, and cancer progression in the Y79 retinoblastoma cell line as well as in the orthotopic and subcutaneous xenograft animal models. Furthermore, magnolol increased the expression of miR-200c-3p. Our results demonstrate that miRNA-200c-3p inhibits EMT progression through the Wnt16/β- catenin/ZEB1/ E-cadherin axis, and the ZEB1 silencing response shows that miR-200c-3p regulates ZEB1-mediated EMT in retinoblastoma. CONCLUSION:
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Authors | Yu-Hung Lai, Wei-Lun Liu, Tsung-Ying Lee, Chung-Wen Kuo, Yu-Ru Liu, Chi-Yuan Huang, Yung-Hsiang Chen, I-Ling Chen, Szu-Hui Wu, Shu-Chi Wang, Po-Yen Lee, Ching-Chih Liu, Jung Lo, Yo-Chen Chang, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yang Li, Po-Len Liu |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 110
Pg. 154597
(Feb 2023)
ISSN: 1618-095X [Electronic] Germany |
PMID | 36603340
(Publication Type: Journal Article)
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Copyright | Copyright © 2022. Published by Elsevier GmbH. |
Chemical References |
- magnolol
- MicroRNAs
- Cadherins
- ZEB1 protein, human
- Zinc Finger E-box-Binding Homeobox 1
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Topics |
- Animals
- Mice
- Humans
- Male
- Epithelial-Mesenchymal Transition
(genetics)
- Retinoblastoma
(drug therapy, genetics)
- Cell Line, Tumor
- MicroRNAs
(genetics, metabolism)
- Cadherins
(metabolism)
- Retinal Neoplasms
(genetics)
- Gene Expression Regulation, Neoplastic
- Cell Movement
(genetics)
- Zinc Finger E-box-Binding Homeobox 1
(genetics, metabolism)
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