Unique Profile of Inflammation and Immune Activation in Pregnant People With HIV in the United States.

Abstract

BACKGROUND:

Little is known about inflammation/immune activation during pregnancy in people with HIV (PWH) and growth in their children who are HIV-exposed and uninfected (CHEU).

METHODS:

Using data from the Pediatric HIV/AIDS Cohort Study and an HIV-seronegative comparison group, we assessed associations of (1) HIV status, mode of HIV acquisition (perinatally vs nonperinatally acquired), and type of antiretroviral therapy (ART) with inflammation/immune activation in pregnancy; and (2) inflammation/immune activation in pregnancy with growth of CHEU at 12 months. Interleukin 6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), soluble(s) TNF-α receptor 1 and 2 (sTNFR1, sTNFR2), sCD14, and sCD163 were measured between 13 and 27 weeks' gestation. Linear regression models were fit to estimate differences between groups for each log-transformed biomarker, adjusted for confounders.

RESULTS:

Pregnant PWH (188 total, 39 perinatally acquired, 149 nonperinatally acquired) and 76 HIV-seronegative persons were included. PWH had higher IL-6, sTNFR1, sCD14, and sCD163 and lower sTNFR2 compared to HIV-seronegative persons in adjusted models. Among PWH, sCD163 was higher in those with perinatally versus nonperinatally acquired HIV and on PI-based versus INSTI-based ART. Higher maternal concentrations of IL-6, sTNFR2, and hs-CRP were associated with poorer growth at 12 months.

CONCLUSIONS:

Maternal HIV status is associated with a distinct profile of inflammation/immune activation during pregnancy, which may influence child growth.

• Authors: Stephanie Shiau, Denise L Jacobson, Yanling Huo, Deborah Kacanek, Lynn M Yee, David B Williams, Lisa B Haddad, Lena Serghides, Kathleen Powis, Rhoda S Sperling, Paige L Williams, Jennifer Jao, Pediatric HIV/AIDS Cohort Study
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 227 Issue 5 Pg. 720-730 (03 01 2023) ISSN: 1537-6613 [Electronic] United States
• PMID: 36592383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• C-Reactive Protein
• Interleukin-6
• Lipopolysaccharide Receptors
• Biomarkers

Topics

• Pregnancy
• Female
• Humans
• Child
• United States
• C-Reactive Protein
• Interleukin-6
• Cohort Studies
• Lipopolysaccharide Receptors
• Inflammation
• Biomarkers
• HIV Infections (complications)
• Acquired Immunodeficiency Syndrome (complications)