Abstract | BACKGROUND:
Taxane-induced peripheral neuropathy (TIPN) is a debilitating adverse effect of cancer treatments with taxanes which may require a reduction or discontinuation chemotherapy and affect clinical and survival outcomes. A number of factors have contributed to the increasing prevalence of TIPN. Nonetheless, limited knowledge exists of potential prechemotherapy blood-based biochemical factors associated with TIPN development. METHODS: We recruited breast cancer patients at seven cancer institutions in China. Participants aged 18 years or older with stage I to III breast cancer who scheduled to undergo primary neoadjuvant and adjuvant chemotherapy with taxanes were eligible. Eligible patients underwent patient-reported neuropathy assessments using the EORTC-CIPN20 questionnaire. Patients completed the questionnaire before commencing treatment and after every cycle. For every patient, we selected the highest TIPN toxicity score for analysis since the first cycle. The posttreatment TIPN severity was compared with blood-based biochemical factors within 30 days before commencing treatment. Independent samples t tests, Mann-Whitney U tests and linear regression were used to identify blood-based and clinical associations with TIPN development. RESULTS: CONCLUSIONS: The findings suggest that breast cancer patients with a higher cumulative chemotherapy dose, lower pretreatment sodium ions, and higher pretreatment chloride ions receiving taxanes should receive closer monitoring to mitigate the development of short-term and long-term TIPN.
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Authors | Jingtong Zhai, Xiaoying Sun, Fang Zhao, Bo Pan, Huihui Li, Zheng Lv, Mengru Cao, Jiuda Zhao, Hongnan Mo, Fei Ma, Binghe Xu |
Journal | Breast (Edinburgh, Scotland)
(Breast)
Vol. 67
Pg. 36-45
(Feb 2023)
ISSN: 1532-3080 [Electronic] Netherlands |
PMID | 36586272
(Publication Type: Multicenter Study, Journal Article)
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Copyright | Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- taxane
- Chlorides
- Paclitaxel
- Taxoids
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Topics |
- Humans
- Female
- Breast Neoplasms
(complications)
- Chlorides
(adverse effects)
- East Asian People
- Paclitaxel
- Taxoids
- Peripheral Nervous System Diseases
(chemically induced)
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