Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: A total of 95 female rats of the Sprague-Dawley strain were used in the study. Plasma concentrations of ADMA, SDMA and L-arginine were quantified and statistically analyzed. RESULTS: Mean ADMA levels were higher in the tumor-bearing group compared to the control group. Mean plasma levels of SDMA and L-Arginine were not significantly different between the groups. The L-ARG/ADMA ratio was lower in rats with tumors compared to controls. CONCLUSION: Histological assessment confirmed expression of ADMA within the tumor cells, which strongly suggests that these tumor cells were the source of ADMA. Other studies are warranted to further explain the role of ADMA in neoplastic diseases.
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Authors | Iwona Malicka, Helena Martynowicz, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Marek Woźniewski, Andrzej Szuba |
Journal | Anticancer research
(Anticancer Res)
Vol. 43
Issue 1
Pg. 97-103
(Jan 2023)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 36585195
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- N,N-dimethylarginine
- Arginine
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Topics |
- Rats
- Female
- Animals
- Rats, Sprague-Dawley
- Arginine
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