Abstract | BACKGROUND: METHOD: We reviewed the records of 543 ESCC patients who underwent subtotal esophagectomy with gastric conduit reconstruction at Kumamoto University Hospital between August 2010 and July 2021. Blood tests for CRP were done on postoperative days (PODs) 1, 3, 5 or 6, and 7 or 8. RESULTS: The mean CRP levels on day 1, day 3, day 5/6, and day 7/8 were 6.68 ± 0.13 mg/dL, 11.49 ± 0.27 mg/dL, 7.48 ± 0.26 mg/dL, and 5.38 ± 0.22 mg/dL, respectively. Mean CRP levels were highest on day 3, and CRP levels after day 3 correlated with grade >2 complications based on the Clavien-Dindo classification. Receiver operating characteristic curve analysis established the optimal cut-off value for CRP day 3 levels to be 12.19 mg/dL. Multivariate logistic regression analyses found that high CRP day 3 levels significantly correlated with grade >2 complications (odds ratio [OR] 3.77, 95% confidence interval [CI] 2.56-5.35; p < 0.001). Moreover, high day 7/8 CRP levels (>3.52) correlated with postoperative survival, and based on multivariate logistic regression analyses, were significantly associated with poor prognosis (hazard ratio 1.67, 95% CI 1.14-2.43; p = 0.008). CONCLUSION: Our findings suggest CRP day 3 levels as a potential biomarker for predicting postoperative complications and that CRP day 7/8 levels have potential prognostic value for ESCC patients after esophagectomy.
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Authors | Kazuto Harada, Chihiro Matsumoto, Tasuku Toihata, Keisuke Kosumi, Masaaki Iwatsuki, Yoshifumi Baba, Mayuko Ohuchi, Kojiro Eto, Katsuhiro Ogawa, Hiroshi Sawayama, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 30
Issue 3
Pg. 1554-1563
(Mar 2023)
ISSN: 1534-4681 [Electronic] United States |
PMID | 36581721
(Publication Type: Journal Article)
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Copyright | © 2022. Society of Surgical Oncology. |
Chemical References |
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Topics |
- Humans
- Esophageal Squamous Cell Carcinoma
- C-Reactive Protein
(metabolism)
- Esophageal Neoplasms
- Esophagectomy
(adverse effects)
- Prognosis
- Retrospective Studies
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