A 19-Year-Old Adolescent with Probable Alzheimer's Disease.

Abstract

Alzheimer's disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient's cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-β 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.

• Authors: Jianping Jia, Yue Zhang, Yuqing Shi, Xuping Yin, Shiyuan Wang, Yan Li, Tan Zhao, Wenying Liu, Aihong Zhou, Longfei Jia
• Journal: Journal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 91 Issue 3 Pg. 915-922 ( 2023) ISSN: 1875-8908 [Electronic] Netherlands
• PMID: 36565128 (Publication Type: Case Reports, Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Fluorodeoxyglucose F18

Topics

• Male
• Humans
• Aged
• Adolescent
• Alzheimer Disease (diagnostic imaging, genetics, cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Fluorodeoxyglucose F18
• Positron-Emission Tomography
• Magnetic Resonance Imaging