Abstract | BACKGROUND: METHODS: A real-world study was conducted using the clinicopathological data of patients with early HER2-positive breast cancer who were admitted to the member hospitals of the Chinese Society of Breast Surgery, Chinese Surgical Society of Chinese Medical Association between March 2019 and December 2020. This study analyzed the efficacy and tolerance of trastuzumab+chemotherapy and trastuzumab+ pertuzumab+ chemotherapy in patients with early HER2-positive breast cancer. The Response Evaluation Criteria in Solid Tumors 1.1 was adopted to evaluate clinical efficacy. The pathological efficacy was evaluated using the MillerPayne grade. The Common Terminology Criteria for Adverse Events (version 5.0) was adopted to evaluate adverse events (AEs). The propensity scores were subjected to propensity score matching using the R language (1:1 matching with a maximum allowable difference of 0.05 between the two groups). Efficacy was compared using the chi-square test, and correlation analysis was performed using linear regression. RESULTS: A total of 1032 patients with early HER2-positive breast cancer met the enrollment criteria and were included in this study. Among these patients, 472 received neoadjuvant trastuzumab+chemotherapy (the trastuzumab group), and 560 received neoadjuvant trastuzumab+ pertuzumab+ chemotherapy (the trastuzumab+pertuzumab group). The overall pathologic complete response (pCR) rate was 47.2% (487/1032), while the pCR rates of the trastuzumab and trastuzumab+pertuzumab groups were 34.5% (163/472) and 57.9% (324/560), respectively, and the difference was significant (P < 0.001). The incidence of grade 4 AEs was 24/321 (7.5%) in the trastuzumab+pertuzumab group, and there were no cases in which the left ventricular ejection fraction decreased by more than 10%. CONCLUSIONS: Patients in the trastuzumab+pertuzumab group had a higher pCR rate than those in the trastuzumab group, and the toxic side effects were tolerable.
|
Authors | Yuanjia Cheng, Hongyu Xiang, Ling Xin, Xuening Duan, Yinhua Liu, Chinese Society of Breast Surgery (CSBrS), Chinese Society of Surgery of Chinese Medical Association |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 135
Issue 19
Pg. 2311-2318
(Oct 05 2022)
ISSN: 2542-5641 [Electronic] China |
PMID | 36535009
(Publication Type: Multicenter Study, Journal Article)
|
Copyright | Copyright © 2022 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. |
Chemical References |
- ERBB2 protein, human
- Receptor, ErbB-2
- Trastuzumab
|
Topics |
- Female
- Humans
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy)
- Neoadjuvant Therapy
- Receptor, ErbB-2
(genetics)
- Stroke Volume
- Trastuzumab
(therapeutic use)
- Ventricular Function, Left
|