American Radium Society (ARS) Appropriate Use Criteria (AUC) for Extrahepatic Cholangiocarcinoma.

Abstract

Although uncommon, extrahepatic cholangiocarcinoma (EHCC) is a deadly malignancy, and the treatment approaches remain controversial. While surgery remains the only cure, few patients are candidates for resection up front, and there are high rates of both local and distant failure following resection. Herein, we systematically review the available evidence regarding treatment approaches for patients with EHCC, including surgery, radiation, and chemotherapy. The evidence regarding treatment outcomes was assessed using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) framework. A summary of recommendations based on the available literature is outlined for specific clinical scenarios encountered by providers in the clinic to guide the management of these patients.

• Authors: Leila T Tchelebi, Krishan R Jethwa, Anna T Levy, Christopher J Anker, Timothy Kennedy, Elliot Grodstein, Christopher L Hallemeier, Salma K Jabbour, Ed Kim, Rachit Kumar, Percy Lee, William Small Jr, Vonetta M Williams, Navesh Sharma, Suzanne Russo
• Journal: American journal of clinical oncology (Am J Clin Oncol) Vol. 46 Issue 2 Pg. 73-84 (02 01 2023) ISSN: 1537-453X [Electronic] United States
• PMID: 36534388 (Publication Type: Systematic Review, Journal Article)
• Copyright: Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Radium

Topics

• Humans
• United States
• Radium
• Area Under Curve
• Cholangiocarcinoma (radiotherapy, pathology)
• Bile Duct Neoplasms (pathology)
• Bile Ducts, Intrahepatic (pathology)