The aim of this study was to investigate the expression of serum
homocysteine (HCY),
procalcitonin (PCT), and
C-reactive protein (CRP) in abdominal
infectious disease and analyze their relationship with the degree of abdominal
infection. We conducted a retrospective study involving 157 patients with abdominal
infections at Xuzhou Central Hospital between January 2016 and October 2019. The patients were composed of
intestinal obstruction (73 cases),
appendicitis (45 cases), perforation of the digestive tract (25 cases), and
cholecystitis (14 cases). The HCY, PCT, and CRP levels of patients with abdominal
infections were detected using
enzyme-linked
immunosorbent assay (ELISA), and correlation analysis between the HCY, PCT, and CRP levels and abdominal
infection was performed using Pearson's correlation analysis. Compared with before treatment, the HCY, PCT, and CRP levels in the four groups decreased significantly
after treatment. The levels in the patients in the
intestinal obstruction group decreased more markedly than in those in the other groups. There were positive correlations among the HCY level, PCT, and CRP before treatment only in patients with
intestinal obstruction (P < 0.001). The difference was statistically significant in the HCY level between the non-operation and the operation groups in patients with
intestinal obstruction (P < 0.001). Serum HCY may be a valuable marker for predicting aggravation of
infection in patients with
intestinal obstruction.