Abstract |
Methods: This study is based on a population-based case-control study of incident prostate cancer (PROtEuS) in men ≤ 75 years of age living in Montreal, Canada, in 2005 to 2012. We included 1172 cases and 1177 population controls. We had personal information, lifetime residential addresses, occupational exposures, and a variety of area-wide covariables. We inferred concentrations of the five VOCs using Bayesian geostatistical models using data from a dense environmental survey conducted in Montreal in 2005 to 2006. We used different sets of adjustments to estimate odds ratios (OR) and confidence intervals. Results: We found nonlinear associations such that the ORs increased monotonically and then either flattened or fell off with increased exposures. The model that contained other environmental variables and contextual variables led to lower ORs and results were similar when we restricted analyses to controls recently screened or tested for prostate cancer or cases with low- or high-grade tumors. A change from the 5th to 25th percentile in mean environmental benzene levels led to an adjusted OR of 2.00 (95% confidence interval = 1.47, 2.71). Conclusion:
|
Authors | Mark S Goldberg, Sara Zapata-Marin, France Labrèche, Vikki Ho, Eric Lavigne, Marie-France Valois, Marie-Elise Parent |
Journal | Environmental epidemiology (Philadelphia, Pa.)
(Environ Epidemiol)
Vol. 6
Issue 6
Pg. e231
(Dec 2022)
ISSN: 2474-7882 [Electronic] United States |
PMID | 36530935
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. |