Efficacy, Tolerability, and Compliance of Direct Acting Antivirals in Patients with HIV and Hepatitis C Coinfection: A Real-Life Experience.

Abstract

Effective management of HIV and hepatitis C virus (HCV) coinfection warrants special emphasis on interactions between direct acting antivirals (DAAs) and antiretroviral therapy (ART) along with maintenance of treatment compliance. All HIV-HCV coinfected adult patients (2015-2020) were included in this real-life retrospective study. Prevalence of coinfection, proportion of coinfected patients treated, compliance rate, sustained virological response at week 12 (SVR12) after the end of therapy, and adverse events were assessed. Among 4578 HIV patients, 232 (5.1%) had HCV coinfection. Ninety-two (39.7%) were intravenous drug users. One hundred twenty-eight (55.1%) patients presented to the liver clinic. Seventy-six (32.8%) patients [mean age: 36.6 ± 10.4 years; 65 (85.5%) males; mean CD4 count: 396 ± 246 cells/mL] completed DAA therapy, whereas 52 (22.4%) patients defaulted and 75 (32.3%) were lost to follow-up. Sixty-seven (82.2%) patients had chronic hepatitis and 9 (11.8%) had compensated cirrhosis. Median (range) HCV-RNA was 5.9 × 106 IU/mL (2.4 × 105-9.9 × 105). Among 15 (19.5%) treatment experienced patients, 14 were pegylated interferon experienced and one was NS5A-inhibitor experienced. ART regimens comprised a combination of tenofovir (T), lamivudine (L), efavirenz (E), nevirapine (N), and/or zidovudine (Z) at dosage and modifications as applicable [TLE: 63 (82.9%), ZLN:11 (14.5%), and ZLE: 2 (2.6%)]. Overall, 74 (97.4%) out of 76 patients who completed DAA therapy achieved SVR12. Adverse events were minor and well-tolerated. HIV-HCV-coinfected patients demonstrate excellent SVR12 and tolerability with available DAAs, with no major adverse events.

• Authors: Saurabh Mishra, Sunil Taneja, Arka De, Nipun Verma, Madhumita Premkumar, G S R S N K Naidu, Aman Sharma, Ajay Duseja, Radha Krishan Dhiman, Virendra Singh
• Journal: AIDS research and human retroviruses (AIDS Res Hum Retroviruses) Vol. 39 Issue 9 Pg. 453-458 (09 2023) ISSN: 1931-8405 [Electronic] United States
• PMID: 36511384 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents

Topics

• Adult
• Male
• Humans
• Middle Aged
• Female
• Antiviral Agents (adverse effects)
• Hepacivirus (genetics)
• HIV Infections (complications, drug therapy)
• Retrospective Studies
• Coinfection (drug therapy)
• Hepatitis C, Chronic (complications, drug therapy)
• Hepatitis C (complications, drug therapy)
• Treatment Outcome