SERS Resolving of the Significance of Acetate on the Enhanced Catalytic Activity of Nanozymes.

Abstract

Understanding the structure-activity correlation and reaction mechanism of the catalytic process in an acetic acid-sodium acetate (HAc-NaAc) buffer environment is crucial for the design of efficient nanozymes. Here, we first reported a lattice restructuration of Au-LaNiO3-δ nanofibers (NFs) after acidification with the HAc-NaAc buffer to show a significantly enhanced oxidase-like property. Surface-enhanced Raman spectroscopy (SERS) and density functional theory (DFT) calculation confirm the direct evidence for the formation of specific enhanced intermediate O-O species after acidification, indicating that the insertion of the carboxyl group in the A-Au/LaNiO3-δ NFs plays crucial roles in both producing vacancies in HAc-NaAc solution from its dissociation during the catalytic process and the protection of the vacancies, which can be directly interacted with oxygen in the environment to produce O-O species, realizing the enhanced oxidation of substrate molecules. The insertion of the carboxyl group increased the oxidase-like catalytic activity by 2.38 times and the SERS activity by 5.27 times. This strategy offers a way to construct an efficient nanozyme-linked immunosorbent assay system for the diagnosis of cancer through the highly sensitive SERS identification of exosomes.

• Authors: Qingnan Zhao, Hai Wang, Wenji Jiang, Huimin Gao, Sisi Wen, Xin Feng, Qiong Wu, Chengyan He, Youliang Zhu, Lianghai Hu, Bing Zhao, Wei Song
• Journal: Analytical chemistry (Anal Chem) Vol. 94 Issue 51 Pg. 17930-17938 (12 27 2022) ISSN: 1520-6882 [Electronic] United States
• PMID: 36509488 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gold
• Oxidoreductases
• Acetates

Topics

• Metal Nanoparticles (chemistry)
• Gold (chemistry)
• Spectrum Analysis, Raman (methods)
• Oxidoreductases
• Acetates