The role of transient receptor potential channels in metastasis.

Abstract

Metastasis is the hallmark of failed tumor treatment and is typically associated with death due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular calcium concentrations and participate at every stage of metastasis. Further, they increase the migratory ability of tumor cells, promote angiogenesis, regulate immune function, and promote the growth of tumor cells through changes in gene expression and function. In this review, we explore the potential mechanisms of action of TRP channels, summarize their role in tumor metastasis, compile inhibitors of TRP channels relevant in tumors, and discuss current challenges in research on TRP channels involved in tumor metastasis.

• Authors: Suwen Bai, Yuan Wei, Rong Liu, Yuhua Chen, Wanling Ma, Minghua Wang, Li Chen, Yumei Luo, Juan Du
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 158 Pg. 114074 (Feb 2023) ISSN: 1950-6007 [Electronic] France
• PMID: 36493698 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Calcium
• Transient Receptor Potential Channels

Topics

• Humans
• Calcium (metabolism)
• Neoplasms (metabolism)
• Transient Receptor Potential Channels (metabolism)
• Neoplasm Metastasis