Novel Platinum(II) and Platinum(IV) Antitumor Agents that Exhibit Potent Cytotoxicity and Selectivity.

Abstract

A novel platinum(II) complex 47OMESS(II) and its platinum(IV) derivative 47OMESS(IV) were synthesized and characterized. Cytotoxicity studies against mesenchymal cells (MCs) and lung (A549), breast (MDA-MB-231), and melanoma (A375) cancer cells demonstrated 7-20-fold superior activity for both complexes relative to cisplatin. Remarkably, 47OMESS(IV) demonstrated 17-22-fold greater selectivity toward the cancerous cells compared to the non-cancerous MCs. Western blot analysis on A549 cells showed the involvement of the intrinsic apoptotic pathway. Cellular fractionation and uptake experiments in A549 cells using ICP-mass spectrometry (MS) indicated that 47OMESS(II) and 47OMESS(IV) cross the cellular membrane predominantly via active transport mechanisms. The significant improvement in selectivity that is exhibited by 47OMESS(IV) is reported for the first time for this class of complexes.

• Authors: Aleen Khoury, Elias Elias, Stephanie Mehanna, Wassim Shebaby, Krishant M Deo, Najwa Mansour, Christian Khalil, Katia Sayyed, Jennette A Sakoff, Jayne Gilbert, Costantine F Daher, Christopher P Gordon, Robin I Taleb, Janice R Aldrich-Wright
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 65 Issue 24 Pg. 16481-16493 (12 22 2022) ISSN: 1520-4804 [Electronic] United States
• PMID: 36480933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Platinum
• Antineoplastic Agents
• Cisplatin

Topics

• Humans
• Platinum (chemistry)
• Antineoplastic Agents (pharmacology, chemistry)
• Cisplatin (pharmacology)
• Apoptosis
• A549 Cells
• Cell Line, Tumor