Current progress in the development of prophylactic and therapeutic vaccines.

Abstract

Vaccines are essential public health tools and play an important role in reducing the burden of infectious diseases in the population. Emerging infectious diseases and outbreaks pose new challenges for vaccine development, requiring the rapid design and production of safe and effective vaccines against diseases with limited resources. Here, we focus on the development of vaccines in broad fields ranging from conventional prophylactic vaccines against infectious diseases to therapeutic vaccines against chronic diseases and cancer providing a comprehensive overview of recent advances in eight different vaccine forms (live attenuated vaccines, inactivated vaccines, polysaccharide and polysaccharide conjugate vaccines, recombinant subunit vaccines, virus-like particle and nanoparticle vaccines, polypeptide vaccines, DNA vaccines, and mRNA vaccines) and the therapeutic vaccines against five solid tumors (lung cancer breast cancer colorectal cancer liver cancer and gastric cancer), three infectious diseases (human immunodeficiency virus, hepatitis B virus and human papillomavirus-induced diseases) and three common chronic diseases (hypertension, diabetes mellitus and dyslipidemia). We aim to provide new insights into vaccine technologies, platforms, applications and understanding of potential next-generation preventive and therapeutic vaccine technologies paving the way for the vaccines design in the future.

• Authors: Tingting Li, Ciying Qian, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia
• Journal: Science China. Life sciences (Sci China Life Sci) Vol. 66 Issue 4 Pg. 679-710 (04 2023) ISSN: 1869-1889 [Electronic] China
• PMID: 36469218 (Publication Type: Journal Article, Review)
• Copyright: © 2022. Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Vaccines, Synthetic
• Vaccines, Attenuated
• Vaccines, Subunit

Topics

• Humans
• Communicable Diseases
• Vaccines, Synthetic
• Communicable Diseases, Emerging
• Vaccines, Attenuated
• Vaccines, Subunit
• Papillomavirus Infections (prevention & control)