Serum Copper-to-Zinc Ratio and Risk of Chronic Obstructive Pulmonary Disease: A Cohort Study.

Abstract

PURPOSE:

Serum copper (Cu), zinc (Zn), and Cu/Zn-ratio have emerged as ageing-related biomarkers. We sought to assess the association between Cu/Zn-ratio and chronic obstructive pulmonary disease (COPD) risk.

METHODS:

Serum Cu and Zn were measured using atomic absorption spectrometry in 2,503 men aged 42-61 years.

RESULTS:

During a median follow-up of 27.1 years, 210 COPD cases occurred. Serum Cu/Zn-ratio and Cu concentrations were linearly associated with COPD risk, whereas the relationship was curvilinear for Zn and COPD risk. A unit increase in Cu/Zn-ratio was associated with an increased COPD risk in multivariable analysis (hazard ratio, HR 1.81; 95% CI 1.08-3.05). The corresponding adjusted HR (95% CI) was 3.17 (1.40-7.15) for Cu. Compared to the bottom tertile of Zn, the HRs (95% CIs) were 0.68 (0.48-0.97) and 1.01 (0.73-1.41) for the middle and top tertiles of Zn, respectively.

CONCLUSIONS:

Increased serum Cu/Zn-ratio and Cu concentrations were linearly associated with an increased COPD risk in men.

• Authors: Setor K Kunutsor, Ari Voutilainen, Jari A Laukkanen
• Journal: Lung (Lung) Vol. 201 Issue 1 Pg. 79-84 (Feb 2023) ISSN: 1432-1750 [Electronic] United States
• PMID: 36464735 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Copper
• Zinc
• Biomarkers

Topics

• Male
• Humans
• Copper
• Zinc
• Cohort Studies
• Pulmonary Disease, Chronic Obstructive
• Biomarkers