Thrombocytopenia after Implantation of the Perceval, Intuity, and Sapien Aortic Valve Prostheses.

Abstract

BACKGROUND:

An increased incidence of thrombocytopenia was reported after implantation of the LivaNova Perceval and the Edwards Sapien aortic valve bioprostheses. Aim of this study is to assess the perioperative platelet count and bleeding complications in three different types of aortic valve bioprostheses intended for high-risk patients, the sutureless LivaNova Perceval, the rapid deployment Edwards Intuity, and the transcatheter Edwards Sapien.

METHODS:

We performed a retrospective analysis of the perioperative data of patients receiving the Perceval, Intuity, and Sapien aortic valve bioprosthesis. The platelet count was collected preoperatively, at nadir postoperatively, and at discharge. The bioprostheses were compared for between-group differences in platelet count and postoperative bleeding complications.

RESULTS:

Overall, 37 patients received the Perceval, 42 the Intuity, and 58 the Sapien bioprosthesis. There was no significant between-group difference in the preoperative platelet count [Perceval 203(178-246)G/l, Intuity 214(190-232)G/l, Sapien 201(178-275)G/l, p = 0.800]. There was a significant between-group difference in the postoperative platelet count, both at nadir value [Perceval 57(37-80)G/l, Intuity 91(73-109)G/l, Sapien 126(105-170)G/l, p < 0.0001] and at discharge [Perceval 150(83-257)G/l, Intuity 239(200-343)G/l, Sapien 232(179-284)G/l, p = 0.001]. There was no significant between-group difference regarding red blood cell transfusions (p = 0.242), platelet transfusions (p = 0.656), and rethoracotomy for bleeding (p = 0.847).

CONCLUSION:

We found a significant platelet count reduction in all three bioprostheses which was more marked in the Perceval group. The platelet count reduction was transient and fully recovered in the Intuity and Sapien groups, whereas the Perceval group showed only a partial platelet count recovery. However, bleeding complications were not different between the three bioprostheses.

• Authors: Achim Haeussler, Vasileios Ntinopoulos, Laura Rings, Nestoras Papadopoulos, Gojart Hoti, Philine Fleckenstein, Omer Dzemali
• Journal: The Thoracic and cardiovascular surgeon (Thorac Cardiovasc Surg) Vol. 71 Issue 7 Pg. 550-556 (10 2023) ISSN: 1439-1902 [Electronic] Germany
• PMID: 36462753 (Publication Type: Journal Article)
• Copyright: Thieme. All rights reserved.

Topics

• Humans
• Aortic Valve (diagnostic imaging, surgery)
• Heart Valve Prosthesis Implantation (adverse effects)
• Aortic Valve Stenosis (diagnostic imaging, surgery, complications)
• Retrospective Studies
• Prosthesis Design
• Treatment Outcome
• Heart Valve Prosthesis (adverse effects)
• Thrombocytopenia (diagnosis, etiology)
• Postoperative Complications (etiology, therapy, epidemiology)
• Bioprosthesis (adverse effects)