Abstract |
Rechallenge of epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKIs) after PD-1 blockade failure was an effective therapy for non-small cell lung cancer (NSCLC) patients with resistance to EGFR-TKIs. The third-generation TKIs, like osimertinib and furmonertinib, can reach higher concentration in the cerebrospinal fluid (CSF) than other TKIs, and exhibit a beneficial effect in NSCLC patients with leptomeningeal metastases (LM) harboring sensitive EGFR mutation. Here, we report that two-stage IV pulmonary adenocarcinoma patients with LM harboring an EGFR L858R mutation benefit from the third-generation EGFR-TKIs rechallenge after immune checkpoint inhibitor (ICI) and anti-angiogenic agent combination therapy. Complete response (CR) to partial response (PR) of central nervous system (CNS) response was achieved immediately after the administration of furmonertinib and osimertinib. We conducted next-generation sequencing (NGS) and IHC to elucidate the evolution of driver mutations and the immune microenvironment. In conclusion, these two cases might provide a therapeutic strategy for further clinical practice. More research was needed to elucidate the resistance mechanisms and improve current treatment strategies in EGFR-mutated patients with LM.
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Authors | Chunfa Qian, Yuhai Zhang, Wanwan Cheng, Qingchao Zhang, Mengzhen Li, Shencun Fang |
Journal | Frontiers in oncology
(Front Oncol)
Vol. 12
Pg. 957661
( 2022)
ISSN: 2234-943X [Print] Switzerland |
PMID | 36457498
(Publication Type: Case Reports)
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Copyright | Copyright © 2022 Qian, Zhang, Cheng, Zhang, Li and Fang. |