Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh.

Abstract

A hernia is a pathological condition caused by a defect or opening in the muscle wall, which leads to organs pushing through the opening or defect. Hernia recurrence, seroma, persistent pain, tissue adhesions, and wound infection are common complications following hernia repair surgery. Infection after hernia mesh implantation is the third major complication leading to hernia recurrence. In order to reduce the incidence of late infections, we developed a polypropylene mesh with antibacterial properties. In this study, knitted polypropylene meshes were exposed to radio-frequency plasma to activate their surfaces. The antibacterial monomer diallyldimethylammonium chloride (DADMAC) was then grafted onto the mesh surface using pentaerythritol tetraacrylate as the cross-linker since it is able to engage all four functional groups to form a high-density cross-linked network. The subsequent antibacterial performance showed a 2.9 log reduction toward Staphylococcus aureus and a 0.9 log reduction for Escherichia coli.

• Authors: Ziyu Wang, Hamid Hamedi, Fan Zhang, Ahmed El-Shafei, Ashley C Brown, Jessica M Gluck, Martin W King
• Journal: ACS applied bio materials (ACS Appl Bio Mater) Vol. 5 Issue 12 Pg. 5645-5656 (12 19 2022) ISSN: 2576-6422 [Electronic] United States
• PMID: 36446396 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polypropylenes
• diallyldimethylammonium chloride
• Anti-Bacterial Agents

Topics

• Humans
• Surgical Mesh (adverse effects)
• Polypropylenes
• Hernia, Ventral (drug therapy)
• Anti-Bacterial Agents (pharmacology)