We report valuable imaging findings in a case of β-
catenin-activated
hepatocellular adenoma (β-HCA) with weak β-
catenin activation. A 40 year-old female presented with a liver
tumor in S8 that was incidentally detected on ultrasonography. The
tumor showed marked enhancement and early venous drainage into the middle hepatic vein in the arterial phase of contrast-enhanced computed tomography (CT). The
tumor revealed slight hypointensity in the hepatobiliary phase of
gadolinium ethoxybenzyl
diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI). Six months after detection, the
tumor had increased in size and a biopsy indicated
hepatocellular carcinoma. The
tumor was resected and pathologically diagnosed as β-HCA with weak β-
catenin activation such as exon 3 S45 mutation and exon 7/8 mutation. Marked enhancement in the arterial phase of CT and MRI is a characteristic finding of β-HCA with weak β-
catenin activation. Furthermore, the degree of β-
catenin activation might determine the signal intensity of β-HCA in the hepatobiliary phase of EOB-MRI.