Biological therapies in the prevention of maternal mortality.
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| Abstract |
Although the maternal mortality rate has decreased and significant improvements have been made in maternal care, maternal death remains one of the substantial problems of our society. The leading causes of maternal death are postpartum hemorrhage, the most important cause of death in developing countries, and preeclampsia and venous thromboembolism, which are more prevalent in developed countries. To treat these conditions, a variety of therapeutic approaches, including pharmacologic agents and surgical techniques, have been adopted. However, a certain number of pregnant women do not respond to any of these options. That is the main reason for developing new therapeutic approaches. Biological medications are isolated from natural sources or produced by biotechnology methods. Heparin is already successfully used in the therapy of deep venous thrombosis and pulmonary embolism. Blood derivatives, used in an autologous or allogenic manner, have proven to be efficacious in achieving hemostasis in postpartum hemorrhage. Mesenchymal stem cells, alpha-1-microglobulin, and antithrombin exhibit promising results in the treatment of preeclampsia in experimental models. However, it is essential to evaluate these novel approaches' efficacy and safety profile throughout clinical trials before they can become a standard part of patient care.
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| Authors | Aleksandar Ljubić, Tatjana Bozanovic, Vesna Piperski, Emilija Đurić, Aleksa Begovic, Marina Sikiraš, Andjela Perovic, Jovana Vukovic, Džihan Abazović |
| Journal | Journal of perinatal medicine (J Perinat Med) Vol. 51 Issue 2 Pg. 253-260 (Feb 23 2023) ISSN: 1619-3997 [Electronic] Germany |
| PMID | 36437561 (Publication Type: Journal Article, Review) |
| Copyright | © 2022 Walter de Gruyter GmbH, Berlin/Boston. |
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