DETERMINATION OF THE SENSITIVITY OF GARDNERELLA VAGINALIS TO FENTICONAZOLE.

Abstract

Objective - to determine the sensitivity of Gardnerella vaginalis to fenticonazole to justify the feasibility of using this mainly antifungal drug for local treatment of BV in cases when it is a multifactorial disease caused by Gardnerella vaginalis and Candida spp. simultaneously.; We observed 98 women with infections of the urogenital tract at the ages of 20 to 49. At the first stage of the study, we analyzed the results of laboratory data on pathological discharge from the urogenital system of these patients. 36 (%) of the examined women had Gardnerella vaginalis in the vaginal discharge. At the second stage of the study, the sensitivity of Gardnerella vaginalis to fenticonazole was determined.; The resistance to fenticonazole was registered in 1 case (2.7%). In the remaining 35 patients Gardnerella vaginalis was not stable to fenticonazole. High sensitivity to this substance was found in 22 of them (61.2%). Respectively, low sensitivity was registered in 13 people from the observation group (36.1%).; Gardnerella vaginalis is the main constituent and a marker of bacterial vaginosis. The elimination of this very microorganism is of paramount importance for its treatment. In 35 studied patients (97.3%) Gardnerella vaginalis, which was isolated by culture from vaginal discharge, had sensitivity to fenticonazole. Moreover, in 22 of them (61.2%) the sensitivity was high, and low in 13 (36.1%). Candida spp. was found in 17 (47.1%) of 36 patients with bacterial vaginosis. It is appropriate to use fenticonazole as a means of local treatment during complex therapy of women with bacterial vaginosis that improves its compliance.

• Authors: P Fedorych, T Kuts, S Koval
• Journal: Georgian medical news (Georgian Med News) Issue 330 Pg. 6-10 (Sep 2022) ISSN: 1512-0112 [Print] Georgia (Republic)
• PMID: 36427832 (Publication Type: Journal Article)

Chemical References

• fenticonazole
• Imidazoles

Topics

• Humans
• Female
• Gardnerella vaginalis
• Vaginosis, Bacterial (drug therapy, microbiology)
• Imidazoles
• Vaginal Discharge
• Candida