Abstract | BACKGROUND: METHODS: RESULTS: Fifty-six patients with borderline resectable-artery pancreatic cancer underwent pancreaticoduodenectomy after neoadjuvant treatment (level 3 group, n = 40; level 2 group, n = 16). The resection level in the level 2 group was changed based on post- neoadjuvant treatment computed tomography images or intraoperative frozen section diagnosis. The overall and local recurrence rates were significantly higher in the level 2 group than in the level 3 group (overall recurrence, 93.8% vs 70.0%; P = .037) (local recurrence, 50.0% vs 5.0%; P < .001). Ten patients experienced local recurrence, of which 8 belonged to the level 2 group. Among them, 4 patients were confirmed as cancer-negative by surgical margin analysis or intraoperative frozen section diagnosis but experienced recurrence around the arteries. CONCLUSION: For treating borderline resectable-artery pancreatic cancer, changing the resection level based on post- neoadjuvant treatment computed tomography images increased the risk of local recurrence. All patients with borderline resectable-artery should undergo level 3 dissection, regardless of the response to neoadjuvant treatment.
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Authors | Kosuke Kobayashi, Yoshihiro Ono, Shoki Sato, Tomotaka Kato, Atsushi Oba, Takafumi Sato, Hiromichi Ito, Yosuke Inoue, Manabu Takamatsu, Akio Saiura, Yu Takahashi |
Journal | Surgery
(Surgery)
Vol. 173
Issue 5
Pg. 1220-1228
(05 2023)
ISSN: 1532-7361 [Electronic] United States |
PMID | 36424197
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Topics |
- Humans
- Neoadjuvant Therapy
(methods)
- Pancreaticoduodenectomy
- Retrospective Studies
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Pancreatic Neoplasms
(drug therapy, surgery)
- Pancreatic Neoplasms
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