Breast adipose metabolites mediates the association of tetrabromobisphenol a with breast cancer: A case-control study in Chinese population.

Abstract

Studies exploring the association of tetrabromobisphenol A (TBBPA) with breast cancer and related mechanisms are limited. To investigate the relationship between TBBPA levels in breast adipose and breast cancer, we carried out case-control research. As well as further examine the mediating role of adipose metabolites between TBBPA and breast cancer using the metabolomics approach. In this study, the concentration of TBBPA was determined utilizing ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) after a solid phase extraction (SPE) pretreatment. High-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) was employed to analyze adipose metabolomics. Evaluation of metabolites linked to TBBPA exposure and breast cancer was performed utilizing mediation analysis. With an estimated OR (95%CI) of 1.153 (1.023, 1.299), TBBPA was firmly linked with breast cancer. We also used propensity score matching analysis and sensitivity analysis to reduce the effect of confounding factors on the results. Metabolomics of adipose suggested significant perturbation in the linoleic acid metabolism pathway. In addition, for PC (16:0/16:0) as phospholipids, a mediation effect on the associations of TBBPA exposure with breast cancer risks was observed (estimated mediation percentage: 56.58%). Understanding the relationship between TBBPA exposure and the risk of breast cancer may be facilitated by the findings, which point to potential mediation metabolites.

• Authors: Ai Zhang, Rui Wang, Qianfeng Liu, Zhengjun Yang, Xiaohui Lin, Jing Pang, Xiaoyu Li, Dan Wang, Jiayu He, Jianping Li, Mingyue Zhang, Yue Yu, Xu-Chen Cao, Xi Chen, Nai-Jun Tang
• Journal: Environmental pollution (Barking, Essex : 1987) (Environ Pollut) Vol. 316 Issue Pt 1 Pg. 120701 (Jan 01 2023) ISSN: 1873-6424 [Electronic] England
• PMID: 36423888 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier Ltd. All rights reserved.

Chemical References

• tetrabromobisphenol A
• Flame Retardants
• Polybrominated Biphenyls

Topics

• Humans
• Female
• Chromatography, Liquid (methods)
• Tandem Mass Spectrometry
• Flame Retardants (analysis)
• Breast Neoplasms
• Case-Control Studies
• Polybrominated Biphenyls (analysis)
• China